A single vape session can increase oxidative stress in nonsmokers’ cells

While the risks that both tobacco and e-cigarettes can pose to normal smoker health are well documented, a new UCLA study shows how quickly vaping affects the cells of healthy young nonsmokers. Indicates whether to do it.

Survey results published in JAMA PediatricsShows that a single 30-minute vaporization session can significantly increase cell oxidative stress. This happens when free radicals (molecules that can damage cells) are out of balance with antioxidants that fight free radicals.

“Over time, this imbalance can play an important role in causing certain diseases such as cardiovascular disease, lung disease, neurological disease, and cancer,” said the lead author of the study. Dr. Holly Middlekauf, a professor of cardiology and physiology at David, said. Gefen School of Medicine, University of California, Los Angeles.

E-cigarettes are devices that supply nicotine with fragrances and other chemicals in steam rather than smoke, and are seen by many as a safer alternative to regular tobacco, but in studies such as Middle Kauf. Inhaling vapors has been shown to be associated with many unfavorable changes in the body that can foresee future health problems.

The current study divided 32 male and female study participants between the ages of 21 and 33 into three groups: 11 nonsmokers, 9 regular cigarette smokers, and 12 Normal e-cigarette smoker. Middlekauff and her colleagues collected immune cells from each individual before and after a 30-minute vaporization session to measure and compare changes in oxidative stress between groups.

The researchers performed the same process during a control session in which participants “sucked fake vapors,” or smoked empty straws, for 30 minutes.

They found that in nonsmokers, oxidative stress levels were 2-4 times higher than before the vaping session. The same 30-minute exposure did not result in an increase in oxidative stress between regular cigarette and e-cigarette smokers, the researchers noted. Probably because the baseline level of oxidative stress has already risen.

“We were amazed at the impact of a single vaporization session on healthy young people,” said Middlekauf. “This short vaping session was the same as what I experienced at a party, but the effect was dramatic.”

The results are particularly awkward, as vaping continues to grow in popularity, especially among teens and young adults, according to researchers. According to a 2020 survey, one in three high school students reported using e-cigarettes last month.

Further understanding is needed to understand exactly what causes changes in oxidative stress levels, whether they are nicotinic or non-nicotinic elements of e-cigarettes. Middlekauf and her team will continue to investigate this question in future research.

“There is a perception that e-cigarettes are safer than tobacco cigarettes, but these findings clearly and clearly show that they do not breathe safe levels of vapor,” said Middlekauf. increase. “The results are clear, clear and worrisome.”

Other authors of this study included Dr. Theodoros Kelesidis, University of California, Los Angeles, Elizabeth Tran, Randy Nguyen, Yuyan Chan, and Grace Sosa.

This study was partially supported by the Tobacco-Related Diseases Research Program in California and the National Institutes of Health.

reference: Kelesidis T, Tran E, Nguyen R, Zhang Y, Sosa G, Middlekauff HR Relationship between a single e-cigarette session and cellular oxidative stress in healthy young people who have never smoked or used e-cigarettes: Randomized clinical cross Over test. JAMA Pediatrics.. 2021. doi: 10.1001 / jamapediatrics.2021.2351

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A single vape session can increase oxidative stress in nonsmokers’ cells

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