T cells induced by COVID-19 infection respond to new viral mutants-US study

(This March 30th article amended the last paragraph to indicate that the treatise was peer-reviewed.)

File photo: The hyperfine morphology of the 2019 Coronavirus (2019-nCoV) can be seen in the illustration released by the Centers for Disease Control and Prevention (CDC) in Atlanta, Georgia, USA on January 29, 2020. ..Dan Higgins, Handouts via MAM / CDC / Reuters / File Photos

Chicago (Reuters)-A key component of the immune system known as T cells that respond to fight infections from the original version of the new coronavirus is of greatest concern, according to a released US laboratory study. It also seems to protect against three new viral variants on Tuesday.

Several recent studies have shown that certain variants of the new coronavirus may weaken the immune defenses from antibodies and vaccines.

However, antibodies that block coronavirus from attaching to human cells may not be able to give the big picture, according to a study by researchers at the National Institute of Allergy and Infectious Diseases (NIAID). T cells appear to play an important additional protective role.

“Our data and other group results show that the T cell response to COVID-19 in individuals infected with the first viral variant fully recognizes the major new mutants identified in the United Kingdom, South Africa and Brazil. It shows that it looks like it is, “said Andrew Red of NIAID and Johns Hopkins University School of Medicine, who led the study.

The researchers analyzed the blood of 30 people who recovered from COVID-19 before the emergence of new, more contagious mutants.

From those samples, we identified specific forms of T cells that were active against the virus and investigated how these T cells function against related mutants in South Africa, the United Kingdom, and Brazil. ..

They found that the T cell response remained largely intact and that virtually all mutations in the studied mutants could be recognized.

The findings add to previous studies that also suggested that T cell protection appears to remain intact against the mutant.

NIAID researchers said larger studies are needed to confirm the findings. Continuous monitoring of mutants that escape protection of both antibodies and T cells is needed, Redd said.

This paper has been peer-reviewed and approved for publication in the Open Forum Infectious Diseases.

Report by Julie Steenhuysen; edited by Bill Berkrot

T cells induced by COVID-19 infection respond to new viral mutants-US study

Source link T cells induced by COVID-19 infection respond to new viral mutants-US study

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