Ivermectin is a Nobel Prize-winning mysterious drug, but not COVID-19 | WGN Radio 720

Ivermectin is over 30 years old Mysterious medicine Treats life-threatening and vision-threatening parasitic infections.Its lasting impact on global health is so serious that two of the leading researchers in its discovery and development 2015 Nobel Prize..

I am Infectious disease pharmacist Over 25 years. I also managed patients who delayed proper treatment of their severe COVID-19 infection because they thought that ivermectin could cure them.

Although ivermectin was a breakthrough for people with certain infections, it cannot save patients from COVID-19 infection. In fact, it can cost their lives.

Let’s talk about a short story about the history of ivermectin.

Development of ivermectin for animals

Ivermectin was first identified in the 1970s. Veterinary drug screening project At Merck Pharmaceuticals. Researchers have focused on discovering chemicals that have the potential to treat parasitic infections in animals. Common parasites include nematodes such as flatworms and roundworms, and arthropods such as fleas and lice. All of these infectious organisms are quite different from viruses.

Merck has partnered with the Kitasato Institute, a Japanese medical research facility. Satoshi Omura and his team have formed a group of chemicals called avermectin. Single soil sample near a Japanese golf course.. As far as I know, avermectin has not yet been found in other soil samples in the world.

Research on avermectin continued for about five years.Soon, Merck and the Kitasato Institute Less toxic form They named it ivermectin. It was approved for commercial use in veterinary medicine in 1981. Parasite infections of livestock and domesticated pets The brand name is Mectizan.

Development of ivermectin for human use

Early experiments William Campbell and his team at Merck have discovered that the drug also works against a human parasite that causes an infection called river blindness.

River blindness, also known as onchocerciasis, that is Second major cause Of preventable blindness in the world.Infects humans from gnats that carry parasites Onchocerca volvulus And it occurs mainly in Africa.

Ivermectin was tested in 1982 for the treatment of river blindness and was approved in 1987. Free distribution Through the Mectisan Donation Program to dozens of countries.Thanks to ivermectin, the blindness of the river Essentially eliminated in 11 Latin American countries, Approximately prevention 600,000 blindness..

These 20 years of extensive work to discover, develop and distribute ivermectin have helped significantly reduce the number of people suffering from river blindness.It is these efforts that have been recognized by 2015 Nobel Prize in Physiology or MedicineAwarded to both William Campbell and Satoshi Omura for leadership in this groundbreaking research.

Diversion of drugs for other uses

Infectious disease researchers often try Reuse antibacterial drugs and other drugs To treat an infectious disease. Drug repositioning is attractive because almost all of the basic research has already been completed, making the approval process faster and cheaper.

In the years since the treatment of river blindness was approved, ivermectin has been shown to be very effective against other parasitic infections.This is also Strongyloidiasis, Intestinal roundworm infection that affects estimation 30 to 100 million people worldwide..

Another example is amphotericin B, which was originally approved for human treatment. Yeast and mold infections..Researchers have also found that it is also effective in treating severe forms Leishmaniasis, A parasitic infection that is widespread in tropical and subtropical countries.

Similarly, doxycycline is an antibiotic used for a variety of human bacterial infections, including: Pneumonia and Lyme disease..Later that too Highly effective In prevention and treatment malaria..

Ivermectin has been used to treat strongyloidiasis, a potentially life-threatening intestinal infection of immunodeficiency. (Getty Images)

Diversion of drugs for COVID-19

However, not all attempts to divert drugs work as expected.

At the beginning of the pandemic, scientists and doctors tried to find Cheap medicine for reuse For the treatment and prevention of COVID-19. Chloroquine and hydroxychloroquine were two of those drugs.They were chosen for their antiviral effects that may be documented in Laboratory research And limited Case report From the first COVID-19 outbreak in China. However, Large clinical trial Of these drugs for treating COVID-19, there was no meaningful benefit.This is partly Serious toxic effects Patients experienced before the drug reached a high dose sufficient to block or kill the virus.

Unfortunately, Lessons from these unsuccessful attempts Not applied to ivermectin. False hopes about using ivermectin to treat COVID-19 Laboratory study in April 2020 In Australia.The result of this study is Widely distributed, I immediately had a serious question.. The levels of ivermectin they tested were 20-2,000-fold higher than the standard doses used to treat human parasitic infections.Indeed, many other pharmaceutical professionals Confirmed my initial concern Within one month from the publication of the paper. Such high concentrations of drugs can be very toxic.

Another commonly cited paper on the effect of ivermectin on COVID-19 is Withdrawal in July 2021 After the scientist A serious flaw was found In research. These deficiencies ranged from inaccurate statistical analysis to discrepancies between collected data and published results, duplicate patient records, and inclusion of study subjects who died before entering the study. Even more worrisome At least two other Frequently cited studies Raised serious concerns about Scientific fraud..

At the time of writing this article, there are two Large-scale randomization Clinical trial In both cases, the use of ivermectin for COVID-19 showed no significant benefit.Reputable national and international medical institutions, including World Health Organization, NS Centers for Disease Control and Prevention, NS National Institute of Health, NS Food and Drug Administration And that Infectious Diseases Society of AmericaIt is unanimously recommended to use ivermectin to prevent or treat COVID-19, unless in the context of clinical trials.

Results of using ivermectin for COVID-19

Unfortunately, many Organizations with suspicious intentions We continue to promote the unfounded use of Invermectin for COVID-19.This led to a dramatic rise Ivermectin prescription When Flood of calls To the US Poison Control Center Overdose of ivermectin.. Many calls were due to high intakes of animal products containing ivermectin – 2 Deaths associated with ivermectin overdose Reported in September 2021.

Ivermectin, when used correctly, has prevented millions of potentially deadly and debilitating infections. It is intended to be prescribed only for the treatment of parasite infections.It is not intended to be prescribed by the parasite you are looking for Withdraw money from Despairing people During a pandemic. I sincerely hope that this unfortunate and tragic chapter of the incredible story of life-saving medicine will end soon.

Ivermectin is a Nobel Prize-winning mysterious drug, but not COVID-19 | WGN Radio 720

Source link Ivermectin is a Nobel Prize-winning mysterious drug, but not COVID-19 | WGN Radio 720

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